Publications
Multi-Centre Evaluation of Verigene® BC-GN Test for Rapid Detection of Gram-Negative Bacteria from Positive Blood Cultures from Pediatric Inpatients
Objectives
Treatment of pediatric Gram-negative bacteremia has become challenging due to the rising incidence of third-generation cephalosporin and carbapenem resistance in Enterobacteriaceae and glucose non-fermenting Gram-negative organisms. This multi-center study evaluated the performance of the rapid Verigene Gram-negative Blood Culture Test (BC-GN) (Nanosphere, Northbrook, IL, USA), a microarray system that detects 9 bacterial targets (Acinetobacter spp., Proteus spp., Citrobacter spp., Enterobacter spp., Escherichia coli, Klebsiella pneumoniae, Klebsiella oxytoca, Pseudomonas aeruginosa, and Serratia marcescens); and 6 antimicrobial resistance determinants (CTX-M, KPC, NDM, VIM, IMP, and OXA) from positive blood culture bottles with Gram-negative organisms seen on Gram stain. The BC-GN is an Investigational Use Only assay at this time.